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1.
为稳定掺入高吸水树脂(SAP)水泥基材料的流动性能,采用反相悬浮聚合法制备了多孔型聚丙烯酸/丙烯酰胺SAP.利用扫描电子显微镜(SEM)观测SAP的微观形貌,通过傅里叶红外光谱(FTIR)分析SAP的分子结构,用“茶袋法”测试SAP的吸液性能,并通过流动度试验研究了非多孔型及多孔型SAP对水泥净浆流动度经时变化的影响.结果表明:多孔型SAP具有微米级连通孔结构,能够有效促进吸水速率,达到吸水平衡只需1 min内;当通过额外引水保持水泥净浆初始流动度相同时,多孔型SAP的掺入对水泥净浆流动度的经时损失影响最小. 相似文献
2.
Nianxiu Duan Junjun Li Sha Song Feng Wang Yiwei Yang Di Nie Caifen Wang Yingjie Sheng Yali Tao Jie Gao Can Xu Yan Wei Yong Gan 《Advanced functional materials》2021,31(46):2100605
Tumor-specific enhanced delivery of chemotherapeutics and modulators to tumor cells and activated pancreatic stellate cells (aPSCs), respectively, represents safer and more effective therapy for pancreatic cancer. Herein, a membrane type 1-matrix metalloproteinase (MT1-MMP)-cleavable spacer is used to assemble low-density cRGDfK onto thermosensitive liposomes loaded with phosphorylated calcipotriol (PCAL) and doxorubicin (DOX), yielding MR-T-PD. The liposome-linked cRGDfK prodrug on MR-T-PD surface is first activated by MT1-MMP, which is selectively expressed on tumor endothelial cells, to release cRGDfK. The free cRGDfK specifically promotes tumor angiogenesis, leading to 3.4-fold higher accumulation and a wider distribution of MR-T-PD in tumors. Furthermore, MR-T-PD rapidly releases PCAL and DOX into the interstitium under heat treatment. The released DOX enters tumor cells to induce apoptosis, whereas the PCAL prodrug is converted to CAL by alkaline phosphatase on the surface of aPSCs; CAL can then enter aPSCs to induce quiescence and promote the antitumor effect of DOX. Finally, by enhancing the exposure of DOX and CAL to tumor cells and aPSCs, respectively, in a tumor-specific manner, MR-T-PD exerts superior efficacy (a 5.9-fold decrease in tumor weight) without causing additional side effects. Overall, this prodrug-based smart liposome system represents a promising paradigm for pancreatic cancer therapy. 相似文献
3.
Yong Li Qiyuan Feng Sihua Li Ke Huang Mangyuan Ma Weiliang Gan Haibiao Zhou Xiangjun Jin Xiao Renshaw Wang Yalin Lu Wen Siang Lew Qingyou Lu Fusheng Ma 《Advanced functional materials》2020,30(3)
Magnetic skyrmions are topologically nontrivial spin structures, and their existence in ferromagnetically coupled multilayers has been widely reported with a disordered arrangement. Here, a nucleation scenario of ordered skyrmions in nanostructured synthetic antiferromagnetic (SAF) multilayers is proposed and experimentally demonstrated using direct magnetization imaging, indirect magnetometer and magnetoresistance measurement, and micromagnetic simulation. Instead of relying on Dzyaloshinskii–Moriya interaction, the antiferromagnetic interlayer exchange coupling in the SAF multilayers fulfills the role of nucleation and stabilization of skyrmions. The robustness of the proposed skyrmion nucleation scenario is examined against temperature from 4.5 to 300 K and device size from 400 to 1200 nm. Interestingly, these synthetic skyrmions still behave well with a size less than 100 nm. The higher stability than generic magnetic domains can be attributed to topological protection. The results thus provide an artificial skyrmion platform to meet the functional needs of high density and designable arrangement in magnonic and spintronic applications. 相似文献
4.
Dr. Feng Wang. Dr. Shan Li Taiping Gan Dr. Gordon M. Stott Dr. Andrew Flint Dr. Tsui-Fen Chou 《ChemMedChem》2020,15(8):685-694
Abstract : A major challenge of targeted cancer therapy is the selection for drug-resistant mutations in tumor cells leading to loss of treatment effectiveness. p97/VCP is central regulator of protein homeostasis and a promising anticancer target because of its vital role in cell growth and survival. One ATP-competitive p97 inhibitor, CB-5083, has entered clinical trials. Selective pressure on HCT116 cells dosed with CB-5083 identified five different resistant mutants. Identification of p97 inhibitors with different mechanisms of action would offer the potential to overcome this class of resistance mutations. Our results demonstrate that two CB-5083 resistant p97 mutants, N660 K and T688 A, were also resistant to several other ATP-competitive p97 inhibitors, whereas inhibition by two allosteric p97 inhibitors NMS-873 and UPCDC-30245 were unaffected by these mutations. We also established a CB-5083 resistant cell line that harbors a new p97 double mutation (D649 A/T688 A). While CB-5083, NMS-873, and UPCDC-30245 all effectively inhibited proliferation of the parental HCT116 cell line, NMS-873 and UPCDC-30245 were 30-fold more potent in inhibiting the CB-5083 resistant D649 A/T688 A double mutant than CB-5083. Our results suggest that allosteric p97 inhibitors are promising alternatives when resistance to ATP-competitive p97 inhibitors arises during anticancer treatment. 相似文献
5.
本文以五跨双塔自锚式悬索桥——成都云龙湾大桥为工程背景,通过建立有限元模型,对该桥空间结构静力特性进行了分析与研究.根据设计需求,分析并讨论了恒载、活载、温度等效应对结构受力的影响,并进行了荷载效应组合下结构受力性能检算,为桥梁设计、施工和运营提供理论依据,同时也为同类型桥梁的设计研究提供参考. 相似文献
6.
Jun Wang Fushuo Wu Ruoan Zou Yueshu Wu Mengdi Gan Jing Feng Xiaoyu Chong 《Journal of the American Ceramic Society》2021,104(11):5873-5882
In this study, high-entropy rare-earth tantalate ceramics (Y0.2Ce0.2Sm0.2Gd0.2Dy0.2)TaO4 ((5RE0.2)TaO4) have been successfully fabricated. The possibility of formation of (5RE0.2)TaO4 was verified via first-principles calculations. In addition, the phase structure, ferroelastic toughening mechanism, thermophysical, and mechanical properties were systematically investigated. The (5RE0.2)TaO4 ceramics have lower phonon thermal conductivity (1.2–2.6 W·m–1·K–1) in the entire temperature range than that of RETaO4 and YSZ. (5RE0.2)TaO4 has a higher fracture toughness and lower brittleness index than YSZ. The thermal expansion coefficients of (5RE0.2)TaO4 are as high as 10.3 × 10-6 K–1 at 1200°C and Young's modulus is 66–189 GPa, and thus, (5RE0.2)TaO4 possesses great potential for application in thermal barrier coatings (TBCs). 相似文献
7.
Tae-min Yeo Jung-Wook Cho Ivan Hung Zhehong Gan Sabyasachi Sen 《Journal of the American Ceramic Society》2022,105(10):6140-6148
The structure of mold flux glasses in the system CaO-(Na,Li)2O-SiO2-CaF2 with unusually high modifier contents, stabilized by the addition of ∼4 mol% B2O3, is studied using 7Li, 23Na, 19F, 11B, and 29Si magic-angle-spinning (MAS), and 7Li{19F} and 23Na{19F} rotational echo double-resonance (REDOR) nuclear magnetic resonance (NMR) spectroscopy. When taken together, the spectroscopic results indicate that the structure of these glasses consists primarily of dimeric [Si2O7]−6 units that are linked to the (Ca,Na,Li)-O coordination polyhedra, and are interspersed with chains of corner-shared BO3 units. The F atoms in the structure are exclusively bonded to Ca atoms, forming Ca(O,F)n coordination polyhedra. This structural scenario is shown to be consistent with the crystallization of cuspidine (3CaO·2SiO2·CaF2) from the parent melts on slow supercooling. The progressive addition of Li to a Na-containing base composition results in a corresponding increase in the undercooling required for the nucleation of cuspidine in the melt, which is attributed to the frustrated local structure caused by the mixing of alkali ions. 相似文献
8.
Yang Jinmeng Zhao Lanhao Shen Zhenzhong Gan Lei Xu Liqun 《Bulletin of Engineering Geology and the Environment》2021,80(3):2671-2685
Bulletin of Engineering Geology and the Environment - In large-scale hydropower projects, the anti-seepage curtain is an important measure to reduce the leakage of reservoirs and ensure the... 相似文献
9.
Yan Huang Honggang Lu Bingnan Wang Wenbo He Hongzhou Dong Lina Sui Zhixing Gan Shuai Ma Beili Pang Lifeng Dong Liyan Yu 《International Journal of Hydrogen Energy》2021,46(5):3530-3538
As a promising catalyst for solar hydrogen production, black phosphorus (BP) has received widespread attention due to variable band gaps, high carrier mobility, and strong light absorption performance. Herein, we use MoS2 as a cocatalyst to synthesize BP/MoS2 catalyst with polycrystalline BP to improve photocatalytic performance under visible light irradiation. A small amount of MoS2 can reduce the recombination of electron-hole pairs in the composite, increase carrier transport efficiency, and then improve photocatalytic performance. As expected, the 10/0.5 ratio of BP/MoS2 catalyst exhibits the highest photocatalytic hydrogen evolution performance with a hydrogen evolution rate of 575.4 μmol h?1 g?1, which is 2.5 times of pure BP. Based on the results above, a simple method is provided to synthesize low-cost black phosphorus-based photocatalysts. 相似文献
10.